(9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Sarcoidosis--Pulmonary

(9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one has been researched along with Sarcoidosis--Pulmonary* in 4 studies

Trials

1 trial(s) available for (9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Sarcoidosis--Pulmonary

Article	Year
Effect of beclomethasone dipropionate (BDP) as extrafine aerosol on bronchoalveolar lavage (BAL) lymphocytes in chronic sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2005, Volume: 22, Issue:3 Patients with pulmonary sarcoidosis can benefit from inhaled corticosteroids. In this study we assessed the effect of beclomethasone dipropionate (BDP), administered as extrafine, HFA(hydrofluoroalkane)-driven aerosol with high peripheral deposition, on bronchoalveolar lavage (BAL) lymphocyte numbers, as a marker of the disease.. Fifteen patients with newly-diagnosed pulmonary sarcoidosis (Stages I-III) received either BDP 800 microg daily (n = 6) or placebo (n = 9) for 6 months in a parallel-group design. Before and after treatment, clinical and radiological states were assessed, bronchoalveolar lavage (BAL) performed, and the cellular composition of BAL fluid as well as cytokine production by BAL lymphocytes determined.. BDP caused a decrease in the percentage of BAL lymphocytes in the BDP (p < 0.05) but not the placebo group. HLA-DR expression on lymphocytes was diminished after BDP (p < 0.05), while intracellular cytokine production by lymphocytes was not altered. Chest radiography suggested an improvement in the BDP group. There was also a rise (p < 0.05) in the diffusing capacity for carbon monoxide.. Though based on a small group of patients, the present findings suggest that in patients with pulmonary sarcoidosis of stage II and minor functional impairment, inhalation of high doses of BDP as extrafine, peripherally deposited aerosol is associated with a reduction in the number of BAL lymphocytes, in parallel with improvements in other markers of the disease. Topics: Administration, Inhalation; Adult; Aerosols; Beclomethasone; Bronchoalveolar Lavage Fluid; Double-Blind Method; Female; Glucocorticoids; Humans; Lymphocytes; Male; Middle Aged; Placebos; Respiratory Function Tests; Sarcoidosis, Pulmonary	2005

Article

Year

Effect of beclomethasone dipropionate (BDP) as extrafine aerosol on bronchoalveolar lavage (BAL) lymphocytes in chronic sarcoidosis.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2005, Volume: 22, Issue:3

Patients with pulmonary sarcoidosis can benefit from inhaled corticosteroids. In this study we assessed the effect of beclomethasone dipropionate (BDP), administered as extrafine, HFA(hydrofluoroalkane)-driven aerosol with high peripheral deposition, on bronchoalveolar lavage (BAL) lymphocyte numbers, as a marker of the disease.. Fifteen patients with newly-diagnosed pulmonary sarcoidosis (Stages I-III) received either BDP 800 microg daily (n = 6) or placebo (n = 9) for 6 months in a parallel-group design. Before and after treatment, clinical and radiological states were assessed, bronchoalveolar lavage (BAL) performed, and the cellular composition of BAL fluid as well as cytokine production by BAL lymphocytes determined.. BDP caused a decrease in the percentage of BAL lymphocytes in the BDP (p < 0.05) but not the placebo group. HLA-DR expression on lymphocytes was diminished after BDP (p < 0.05), while intracellular cytokine production by lymphocytes was not altered. Chest radiography suggested an improvement in the BDP group. There was also a rise (p < 0.05) in the diffusing capacity for carbon monoxide.. Though based on a small group of patients, the present findings suggest that in patients with pulmonary sarcoidosis of stage II and minor functional impairment, inhalation of high doses of BDP as extrafine, peripherally deposited aerosol is associated with a reduction in the number of BAL lymphocytes, in parallel with improvements in other markers of the disease.

Topics: Administration, Inhalation; Adult; Aerosols; Beclomethasone; Bronchoalveolar Lavage Fluid; Double-Blind Method; Female; Glucocorticoids; Humans; Lymphocytes; Male; Middle Aged; Placebos; Respiratory Function Tests; Sarcoidosis, Pulmonary

2005

Other Studies

3 other study(ies) available for (9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Sarcoidosis--Pulmonary

Article	Year
Failure of inhaled corticosteroids to improve small airway obstruction in two patients with sarcoidosis. Respiration; international review of thoracic diseases, 2002, Volume: 69, Issue:1 Topics: Administration, Inhalation; Adult; Airway Obstruction; Beclomethasone; Bronchoalveolar Lavage; Bronchoscopy; Female; Humans; Middle Aged; Recurrence; Sarcoidosis, Pulmonary; Tomography, X-Ray Computed; Treatment Failure	2002
[A case of sarcoidosis exacerbated during improvement of bronchial asthma]. Arerugi = [Allergy], 2001, Volume: 50, Issue:4 Topics: Administration, Inhalation; Anti-Asthmatic Agents; Asthma; Beclomethasone; Female; Humans; Middle Aged; Sarcoidosis, Pulmonary	2001
Inverse association between sarcoidosis and atopic asthma. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 1998, Volume: 15, Issue:2 Topics: Acute Disease; Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Beclomethasone; Follow-Up Studies; Humans; Male; Sarcoidosis, Pulmonary; Theophylline	1998